In 1827, the forensic physician, writer, and poet Johann Baptist Friedreich (1796–1862) founded the Philosophical-Medical Society of Würzburg, which was already integrated into the newly founded Physico-Medical Society by 1853. According to the statutes of 1827, the Society aimed "to cultivate all branches of medical and philosophical knowledge to the best of its ability and to share the results of its research […] with the scholarly world in the yearbooks to be published by the Society."

Under Friedreich’s leadership, there were two attempts to establish a periodical as the Society’s own publication organ. In 1828, three issues of the Yearbooks of the Philosophical-Medical Society of Würzburg were printed and published by Carl Strecker. No further volumes appeared thereafter. After a two-year hiatus, a single issue of the New Yearbooks of the Royal Philosophical-Medical Society of Würzburg was published in 1830. In its preface, the "previous yearbooks of the Society were declared closed with the third issue of the first volume, and a new sequence of the journal was thereby inaugurated, in which one section would contain essays related to the natural and medical sciences, and the other would present works on philosophy and history." Although the revised statutes of 1831 reflected and solidified this division, stating that the New Yearbooks of the Royal Philosophical-Medical Society of Würzburg "must appear at least once a year," this publishing effort did not progress beyond the first volume.