Beginning in 1868/69, the Proceedings of the Physico-Medical Society of Würzburg were published under the title New Series. These volumes contained contributions from renowned scientists and Nobel laureates, including the seminal report on the discovery of X-rays in 1896.

The first two volumes of the Proceedings were published by Ferdinand Enke Verlag in Erlangen. From the third volume, published in 1852, printing and distribution were taken over by Stahel'sche Buchhandlung in Würzburg. The publication of the Proceedings was temporarily suspended after the tenth volume in 1860. Between 1861 and 1867, the Physico-Medical Society published two other periodicals in place of the Proceedings: the Würzburg Medical Journal and the Würzburg Natural Science Journal. In 1868, the Proceedings were re-established under the title New Series, with printing once again handled by Stahel'sche Kunst- und Buchhandlung. Prominent members of the Society, such as Professors Albert von Koelliker (1817-1905) and Friedrich Wilhelm Scanzoni von Lichtenfels (1821-1891), continued to oversee the editorial process.

The Proceedings also included the printed minutes of the Physico-Medica for the years 1849 to 1859, as well as 1868/69 to 1934/35, though these were only consolidated into a separate section of each year’s volume starting in 1852. Between 1860 and 1866/67, the minutes appeared concurrently in two other publications, which temporarily replaced the Proceedings: the Würzburg Medical Journal and the Würzburg Natural Science Journal.

From time to time, the New Series of the Proceedings included additional supplements, such as the Medical Statistics of the City of Würzburg (1871-1898), Pharmacological Investigations (1873-1882), and a report on the psychiatric department of the Julius Hospital (1870).